Macrophages, integral components of the immune system, play a crucial role in maintaining homeostasis and combating infections. In recent years, researchers have uncovered the diverse applications of macrophages in disease treatment research.   Atherosclerosis, a leading cause of cardiovascular diseases, involves the accumulation of plaques within arterial walls. Macrophages contribute significantly to the progression and resolution of atherosclerotic lesions. When low-density...

Liver cancer, specifically hepatocellular carcinoma (HCC), is one of the leading causes of cancer-related deaths worldwide. The tumor microenvironment, which includes various immune cells, plays a significant role in cancer progression and response to therapy. Among these immune cells, macrophages have been identified as key players due to their diverse functions and plasticity. The Role of Macrophages in Liver Cancer Recent studies have highlighted the crucial role of macrophages in liver...

Glycans, also known as carbohydrates or polysaccharides, are fundamental constituents of all cellular life. They play essential roles in various biological processes, including cell-to-cell communication, immune response, and disease progression, among others. Accurate glycan purification, glycan identification, and anti-glycan antibody assays are crucial in advancing our understanding of glycans and their roles in biology and medicine.   Glycan purification is a critical initial...

In the intricate realm of medical diagnostics and therapeutic advancements, antibodies targeting glycans have emerged as pivotal players. Glycans, complex sugar molecules decorating proteins and lipids, play crucial roles in cellular communication, immune responses, and disease pathogenesis. Harnessing antibodies specific to these glycans opens new avenues for diagnosis, treatment, and biomedical research.   Glycans are diverse carbohydrate structures attached to proteins and lipids,...

Microfluidic chips have garnered significant interest from both academic and industrial sectors since their inception. The launch of the journal "Lab on a Chip" in 2001 marked a pivotal moment, quickly establishing itself as a cornerstone publication and catalyzing further global research in microfluidic chips. In 2004, Business 2.0 magazine featured chip laboratories prominently, identifying them among the "seven technologies that will change the future" on its cover. Subsequently, in July...

Microfluidics and biosensor technologies are rapidly transforming the biomedical and biotechnology landscapes, offering unprecedented precision, efficiency, and scalability. These innovations are driving breakthroughs in diagnostics and drug development, making them indispensable tools for researchers and industry professionals alike. Recent developments in these fields highlight the growing demand for advanced fabrication and development services, which are enabling the creation of...

The Kinesins Gene Family is a critical group of motor proteins responsible for a wide array of cellular processes, ranging from intracellular transport to mitotic spindle assembly. These ATP-dependent molecular motors move along microtubules and are essential for proper cell division, neuronal function, and organelle positioning. Understanding kinesin family structure, regulation, and expression has become a central focus in biomedical research.   The Kinesins Gene Family:...

Stable isotope labeling is a powerful technique widely employed in analytical chemistry, proteomics, metabolomics, and molecular biology. It involves the incorporation of non-radioactive isotopes, such as carbon-13 (¹³C), nitrogen-15 (¹⁵N), or deuterium (²H), into molecules to trace biological pathways, quantify biomolecules, and study dynamic processes within living organisms. Unlike radioactive labeling, stable isotope labeling poses no radiological hazards, making...

    Alfa Cytology has revealed new FAP-targeted therapeutics development services that aim to develop precise and effective cancer treatments.   Alfa Cytology has introduced its groundbreaking initiative which targets fibroblast activation protein(FAP) for cancer therapies. These solutions focusing on FAP to improve treatment accuracy and deliver customized projects that strive to obtain more comprehensive research results through experiments.   The...

    Cancer treatment has witnessed transformative advancements over the past few decades, notably with the emergence of CAR-T (Chimeric Antigen Receptor T-cell) therapy. This revolutionary therapy harnesses the body's immune system by genetically engineering T-cells to target and destroy cancer cells. Among the pioneering companies at the forefront of this innovation is Alfa Cytology, renowned for its cutting-edge preclinical alfaCAR-T solutions.   Understanding CAR-T Therapy...

Nanopore sequencing is a rapidly maturing length-based sequencing technology capable of analyzing natural DNA/RNA and sequencing fragments of any length, from short to ultra-long, making it possible to elucidate all types of genetic and epigenetic variation. However, while this technology has improved in recent years, it still exhibits relatively high error rates on raw sequences in the range of 5% to 15% when compared to standard next-generation sequencing (NGS) devices such...

At CD Genomics, we pride ourselves on the quality of the long-read sequencing data we generate for Pacific BioSciences (PacBio) and Oxford Nanopore Technology (ONT). High-quality sequencing data is the ultimate goal of next-generation sequencing. Since the final quality is largely dependent on the quality of the starting material, it is important to ensure high-quality starting material. Unlike DNA, RNA is a highly sensitive nucleic acid that can be easily...